BIOTECH

Imagine having the health and energy of your early twenties combined with the wisdom of age.

Biotechnology could help us unlock the secrets to extending lifespans and improving quality of life. This technology might reliably extend chronological age enough to be on track for longevity escape velocity, enabled by widespread access to longevity therapeutics, aging clocks to measure progress, and reversible cryonic biopreservation as an alternative.

Learn all about biotech under "Intro," understand potential risks under "Risks," discover the most hopeful scenarios under "Hope," and find out how to get involved under "Action."

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BIOTECH

Longevity: Extending Healthy Lifespan

Longevity FAQ - Nintil. Covers major longevity concepts and misconceptions. Forum/blog-post
Fight Aging FAQ - Reason. Covers major longevity concepts and misconceptions. Forum/blog-post
Longevity FAQ - Laura Deming. Covers main longevity concepts and misconceptions. Forum/blog-post
Longevity Acceleration Roadmap. Covers bioengineering, replacement and biostasis as focus areas. Website/blog
Bottlenecks of Aging Roadmap. Comprehensive roadmap of bottlenecks in the longevity field. Misc.
Longevity Tech Tree - Foresight Institute. Technology trees to reach escape velocity in longevity. Misc.
Longevity Technology - Aaron King. An overview of the state of the art and major challenges in longevity. Misc.
How to Cure Aging, What Are You Doing With Your Life? - Kurzgesagt. Explainer videos on aging. Video
Your Life in Weeks, You’re at the tail end of your life - Tim Urban. Post that breaks down a human life into weeks, and breaks down time remaining into chunks of experiences to be had. Forum/blog-post
A Systematized Roadmap for the Longevity Industry - Biogerontology Research Foundation. Misc.
A Reimagined Research Strategy for Aging - SENS. Dated but still considered a good overview of main aging areas to solve. Forum/blog-post
How to Start a Biotech Company in the Longevity Industry - Reason. Practical advice for entrepreneurs in the longevity space. Forum/blog-post
It Is Time To Classify Biological Aging as a Disease - Bulterijs, Hull, Björk, and Roy. On the benefits of classifying aging as a disease, especially for FDA approval of aging drugs. Academic paper
A Nuanced Opposition to the FDA - Reason. Why the current FDA drug approval process is a major roadblock on advancing longevity progress. Forum/blog-post
100 Plus - How The Coming Age of Longevity will change everything - Sonia Arrison. Thematic overview of how major areas in our lives will be changed with increased healthspans. Book
AI in Life-Extension: From Deep Learning to Superintelligence - Mikhail Batin et al. From near-term benefits of AI for longevity to potential futuristic implications of AI for longevity. Academic paper
Creon’s Life Extension References - Creon Levit. Link list on life extension and diet. Content list
The Ethics of Ageing Biology – Andrew Steele. Blog exploring science, technology, and the complexities of getting older without getting old. Forum/blog-post

Cryonics: Beyond Death

Why Cryonics Makes Sense - Tim Urban. A primer on why it makes sense to sign up to cryonics. Forum/blog-post
Cryonics - Reason. A brief explainer on the main concepts and controversies in cryonics. Forum/blog-post
The Future Loves You - Ariel Zelewnikow-Johnston. A book about why we should abolish death with a strong focus on cryonics. Book
Cryostasis Revival - Robert Freitas. A book about nanomedicine for revival. Book
Cryonics: Alcor FAQ - Alcor. An FAQ about cryonics, and about the practices of the provider Alcor. Forum/blog-post
Alcor vs. Cryonics Institute - Lesswrong. A comparison of Alcor versus the Cryonics Institute as providers for cryonics services. Now there is also TomorrowBiostasis, a European Cryonics Company. Forum/blog-post
Winter is Coming : the Future of Cryonics Preservation – Sanja Bojic, et al. Reviews current cryopreservation methods and explores future prospects in the context of organ transplantation and regenerative medicine. Academic paper
Cryonics Cost-Benefit Analysis – Niplav. Cost-benefit analysis on whether it's worth it to invest money into cryonics, and if it's smart to sign up for it now or wait until later. Academic paper

Biotech: Shaping Life's Next Frontier

Benefits & Risks of Biotechnology - FLI. Introductory post with link list. Forum/blog-post
Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves - George Church. An optimistic outlook into biotechnology’s promises by one of the pioneers of the field. Video
Liberation Biology: The Scientific and Moral Case for the Biotech Revolution - Ronald Bailey. A moral argument in favor of advancing biotechnology. Book
Life As It Could Be: Astrobiology, Synthetic Biology, and the Future of Life - Library of Congress. A longish but interesting live stream of a synbio conference giving a good overview of the state of the art in the field. Video
CRISPR - Kurzgesagt. Illustrative explainer video on CRISPR and designer babies. Video

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Biotech

Biosecurity - EA Forum. Landing page to EA’s biosecurity section with intro to the topic and a list of links, such as A Biosecurity and Biorisk Reading List - Tessa Alexanian. Forum/blog-post
Existential Risk and Cost-effective Biosecurity - Piers Millett and Andrew Snyder-Beattie. Focuses on addressing risks from bioweapons. Academic paper
Insidious Insights: Implications of Viral Vector Engineering for Pathogen Enhancement - Jonas Sandbrink et al. On dual-use insights relevant to the enhancement of pandemic pathogens. Academic paper
SecureBio Recommendations for AI and Biosecurity - SecureBio. Letter to NIST provides guidelines for integrating AI into biosecurity measures. It outlines best practices for ensuring the safety and effectiveness of AI technologies in managing biological threats, emphasizing robust security protocols and ethical considerations. Misc.
How a Deliberative Pandemic Could Crush Societies and What To Do About It - Kevin Esvelt. Podcast episode with transcripts on biosecurity and pandemics. Audio

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Longevity

The Fable of the Dragon Tyrant - Nick Bostrom. Much-cherished fairy-tale-like story illustrating the loss incurred by aging and our deathist acceptance.
Childhood’s End - Arthur C. Clarke. Fictional account of the end of death.
San Junipero - BlackMirror. About a love story in the afterlife.
Death & Anti-Death Series - Charles Tandy. Dated but contains various optimistic longevity-focused contributions.
Altered Carbon - TV series. Not always positive.
In Time - Movie. A society in which people stop aging.
Longevity Tree 1, Longevity Tree 2, Biotech Tree - Foresight Institute. Technology trees to reach escape velocity in longevity.

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Biotech

The Hedonistic Imperative - David Pearce. A manifesto-like book on the benefits of biotech, neurotech, and similar technologies to enable humans escape our hedonic treadmill.
The Transhumanist Reader - Natasha Vita-More, Max More. A now dated book with various chapter contributions by major transhumanist writers.
Crazy Ideas for Future Synbio & Bioengineering - Stephen Malina. Lists potential future goals and applications in biotechnology.
Envisioning a world immune to global catastrophic biological risks – Carl Schulman, Reflective Disequilibrium. Discusses how DNA/RNA sequencing technology presents a pathway to early detection and containment of pathogens, which could manage both natural pandemics and future biological attacks.

Staying up to Date

Michael Lustgarten, BluePrint, SlowMyAge, Howisfelix.today - Personal longevity tracking and improvement blogs. Forum/blog-post
Lifespan.io - Explainers, news, roadmaps, and other resources. Website/Blog‍
Longevity List - Nathan Cheng. Newsletter and list on major longevity companies.

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Organizations and Projects

Vitalism - A moral philosophy and community of action to form a movement to achieve radical life extension.
Thoughtsformlife, Academic Lectures, Levin Lab - Michael Levin. Work at the forefront of biotechnology, including work on engineering embodied minds, regeneration, and collective biological intelligence. Website/platform
Senescence.info - Overview of the longevity field. Website/Blog
FightAging has an extensive list of funds, nonprofits and blogs of interest listed on the right-handside and is itself a great resource.
Agingbiotechinfo - Karl Pfleger. Covers companies, conferences, diagnostics, resources, and more.
Longevity Prize - VitaDAO & Foresight Institute. Awarding outstanding progress in longevity research — crowdsourced and curated by leading industry experts.
Longevity Biotech Fellowship - A fellowship dedicated to supporting individuals seeking to radically advance longevity biotechnology.
Foresight Longevity Program - Foresight institute. The program includes fellowships, seminars, and workshops to support progress in longevity.
ARPA-H - The Advanced Research Projects Agency for Health (ARPA-H) is a research funding agency that supports transformative biomedical and health breakthroughs – ranging from the molecular to the societal – to provide health solutions for all.
Amaranth Foundation - The Amaranth Foundation funds ambitious longevity breakthroughs.
Impetus Grants - The Impetus Grants fund bold longevity science.
Biosecurity Course - A free course on biosecurity. Misc.
Cambridge Working Group - Works to address the risks of Potential Pandemic Pathogen research through promoting public understanding, risk assessment and regulation of such research.
Biomedical Advanced Research and Development Authority (BARDA) - Develops and procures needed medical countermeasures (MCMs), including vaccines, therapeutics, diagnostics, and non-pharmaceutical countermeasures, against a broad array of public health emergencies in the US.
SecureDNA - A free, cryptographically secure to screen all DNA synthesis for potential hazards .
Biosecurity & Pandemic Preparedness - OpenPhil grant website for biosecurity projects.
Far Out Initiative - A public benefit biotech company dedicated to revolutionizing genetic and pharmacological research to eliminate maladaptive and involuntary suffering in all sentient beings, including human and non-human animals.
Arc Institute - A new institution for curiosity-driven biomedical science and technology. Arc’s mission is to accelerate scientific progress, understand the root causes of disease, and narrow the gap between discoveries and impact on patients.‍
VitaDAO - VitaDAO is a decentralized autonomous organization that funds and supports research projects aimed at tackling aging and age-related diseases.